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This chemical is meant for research and identification of Houses, in Exclusive rooms, on Exclusive laboratory machines, in compliance with all basic safety actions.

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Tolerance Enhancement : As opposed to morphine, which induces major tolerance, this compound confirmed decreased tolerance in the hot plate examination and preserved analgesic efficacy eventually

Q. How can this compound's pharmacological profile be optimized to lessen Unwanted side effects whilst maintaining analgesia?

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Standardize Agonist Publicity Instances : this compound’s gradual dissociation kinetics demand prolonged observation periods to capture comprehensive β-arrestin recruitment .

This compound is actually a research material and is intended for examine in specifically equipped laboratories.

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It does not substantially induce βarrestin2 recruitment into the MOR at concentrations beneath ten μM, suggesting its system of motion mainly consists of signaling via G proteins in lieu of βarrestin2 pathways.

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